A Quick Procedure for the Preparation of 1-N,N-Dialkylamino-1-Buten-3-Ynes

L. Brandsma Department of Preparative Organic Chemistry of, The University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

H. D. Verkruijsse Department of Preparative Organic Chemistry of, The University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

Abstract

1-N,N-Dialkylamino-1-buten-3-ynes, HC°CCH[tbnd]CHNR₂ (R [dbnd] CH₃ or C₂H₅, E / Z ratio ∼ 97: 3) have been prepared in 80 and 84% yields by treating the Mannich-coupling products from HC[dbnd]CCH₂OCH₃ and R₂NCH₂OH, CH₃OCH₂C[tbnd]CCH₂NR₂, with two equivalents of potassium amide in liquid ammonia and subsequently adding methanol or ammonium chloride.

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A Quick Procedure for the Preparation of 1-N,N-Dialkylamino-1-Buten-3-Ynes

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A Quick Procedure for the Preparation of 1-N,N-Dialkylamino-1-Buten-3-Ynes

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