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Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 22, 1992 - Issue 6

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Synthesis of (3R)- and (3S)-3,4-Diamino-Butyric Acid from L-Aspartic Acid

D. Misiti Dip. Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita “La Sapienza”, P.le A. Moro 5, 00185, Roma, Italy

M. Santaniello Lab. Ricerca Chimica, Sigma Tau S.p.A., Via Pontina km 30.400, 00040, Pomezia, Italy

G. Zappia Dip. Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita “La Sapienza”, P.le A. Moro 5, 00185, Roma, Italy

Pages 883-891 | Received 30 Sep 1991, Published online: 23 Sep 2006

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https://doi.org/10.1080/00397919208020852

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Abstract

A short and convenient synthesis for both enantiomers of GABOB amino-analogue 1a,b is reported, starting from L-aspartic acid. The protected diester 3 is the common intermediate for the synthetic pathway.

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