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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 1
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Original Articles

Improved Practical Synthesis of a Prostaglandin and Carbocyclic Nucleoside Synthon

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Pages 151-157 | Received 11 Jul 1991, Published online: 23 Sep 2006
 

Abstract

An efficient, four step synthesis of chiral enone 2a [(+)-2,3-(isopropylidenedioxy)-4-cyclopentenone]from diol 1a (X = Cl), available from microbial oxidation of chlorobenzene, is described. This synthesis is a vast improvement over that previously reported and compares very favorably with others in the literature.

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