Convenient Synthesis of (±)1′, 2′-Seco-2′, 3′-Methanonucleosides

Abstract

The racemic 1′,2′-seco-2′,3′-methanonucleosides have been synthesized by a five step chemical sequence. In this way (±)-1-[(1′-hy-droxy-3′,4′-methylene-but-2′-oxy)methyl]cytosine 6c , thymine 6a , and uracil 6e and (±)-9-[(1′-hydroxy-3′,4′-methylene-but-2′oxy)methyl]adenine 6d and guanine 6b have been obtained and their antiviral evaluation is reported