A Novel Asymmetric Synthesis of S-(+)-2-Amino-4-Phosphonobutanoic Acid

Xian-Yun Jiao Institute of Applied Chemistry. Beijing Agricultural University, Beijing, 100094, People's Republic of China

Wan-Yi Chen Institute of Applied Chemistry. Beijing Agricultural University, Beijing, 100094, People's Republic of China

Bing-Fang Hu Institute of Applied Chemistry. Beijing Agricultural University, Beijing, 100094, People's Republic of China

Abstract

A novel asymmetric synthetic route to S(+)-2-amino -4-pbosphonobutanoic acid through the cyclic condensation of ethyl-4-diethoxyphosphonyl-2-oxo-butanoate with L-erythro-(+)-1, 2-diphenyl-2-hydrozyethylamine, followed by reduction and hydrolysis is described.

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A Novel Asymmetric Synthesis of S-(+)-2-Amino-4-Phosphonobutanoic Acid

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A Novel Asymmetric Synthesis of S-(+)-2-Amino-4-Phosphonobutanoic Acid

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