Abstract
Treatment of 1,2-dibromopropane (1) with 3 equiv of lithium diisopropylamide (-60°; to 0 °C, THF) generates 1-propynyllithium (2), which with aldehydes or ketones affords acetylenic carbinols 3 in 82-96% yields.
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 20
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