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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 22, 1992 - Issue 13
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Original Articles

An Improved Preparation of Aromatase Inhibitor 4-Hydroxyandrost-4-ene-3,17-dione

Pier Giuseppe Ciattini Dipartimento di Studi Farmaceutici e Centro di Studio per la Chimica del Farmaco del C.N.R., Università ‘La Sapienza’, 00185, Roma, Italy
,
Enrico Morera Dipartimento di Studi Farmaceutici e Centro di Studio per la Chimica del Farmaco del C.N.R., Università ‘La Sapienza’, 00185, Roma, Italy
&
Giorgio Ortar Dipartimento di Studi Farmaceutici e Centro di Studio per la Chimica del Farmaco del C.N.R., Università ‘La Sapienza’, 00185, Roma, Italy
Pages 1949-1952 | Accepted 03 Mar 1992, Published online: 23 Sep 2006
 
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Abstract

The title compound has been prepared in 47% overall yield from androst-4-ene-3,17-dione (1) by a two-step sequence comprising hydrox-ylation of 1 with OsO4/H2O2, followed by dehydration of the resultant diols 3 in alkaline medium.

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