A Facile Conversion of 2-Substituted Acrylamides to 1,3-Disubstituted 3-Bromo-2-azetidinones

Sigeru Torii Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama, 700, JAPAN

Hiroshi Okumoto Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama, 700, JAPAN

Hidehiko Yabuki Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima-naka, Okayama, 700, JAPAN

Abstract

N-Substituted 2,3-dibromo-2-alkylacrylamides obtained by the bromination of 2-alkylacrylamides were converted to 1,3-disubstituted 3-bromo-2-azetidinones in excellent yields upon treatment with potassium carbonate in acetone under refluxing.

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A Facile Conversion of 2-Substituted Acrylamides to 1,3-Disubstituted 3-Bromo-2-azetidinones

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A Facile Conversion of 2-Substituted Acrylamides to 1,3-Disubstituted 3-Bromo-2-azetidinones

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