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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 24, 1994 - Issue 11
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Original Articles

Formamidine as a Versatile Protecting Group for Primary Amines: A Mild Procedure for Hydrolytic Removal

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Pages 1617-1624 | Received 04 Nov 1993, Published online: 23 Sep 2006
 

Abstract

A mild, zinc chloride-promoted cleavage of N,N-dimethyl-formamidine derivatives of primary amines to the free amines is described. Under slightly different hydrolytic conditions the corresponding N-formyl derivatives can be isolated.

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