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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 5
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Original Articles

The Boekelheide Reaction: Trifluoroacetic Anhydride as a Convenient Acylating Agent

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Pages 629-633 | Received 31 Aug 1994, Published online: 23 Sep 2006
 

Abstract

2-Alkyl substituted pyridine N-oxides react with trifluoroacetic anhydride at room temperature to give selectively and with high yields the corresponding 2-(α-hydroxyalkyl)-pyridines.

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