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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 5
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Original Articles

Fluorination at C2′, C3′ and C5′ of Nucleosides with 1-Chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octane bis(Tetrafluoroborate) SelectfluorTM Reagent

G. Sankar Lal Corporate Science and Technology Center, Air Products and Chemicals, Inc., 7201, Hamilton Boulevard, Allentown, PA, 18195-1501
Pages 725-737 | Received 04 Aug 1994, Published online: 23 Sep 2006
 
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Abstract

Electrophilic fluorination of thioaryl ethers on the sugar component of nucleosides with commercially available SELECTFLUORTM reagent provides a new method for the synthesis of C2′, C3′ and C5′ fluoronucleosides.

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