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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 18
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Original Articles

Synthesis of Iodoalkylacylates and Their Use in the preparation of S-Alkyl Phosphorothiolates

Radhakrishnan P. Iyer Hybridon Inc., One Innovation Drive, Worcester, MA, 01605
,
Dong Yu Hybridon Inc., One Innovation Drive, Worcester, MA, 01605
,
Nan-hui Ho Department of Chemistry, Tufts University, Medford, MA, 02155
&
Sudhir Agrawal Hybridon Inc., One Innovation Drive, Worcester, MA, 01605
Pages 2739-2749 | Received 04 Jan 1995, Published online: 16 Feb 2007
 
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Abstract

Synthesis of iodoalkylacylates 3a-f and use of 3 c in the preparation of an oligonucleoside phosphorothiate prodrug analog 5 is described.

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