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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 7
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Original Articles

Regiospecific Synthesis of Unsymmetrical α-Bromoketones

Robert E. Boyd R. W. Johnson Pharmaceutical Research Institute Welsh & McKean Roads, Spring House, Pennsylvania, 19477-0776
,
C. Royce Rasmussen R. W. Johnson Pharmaceutical Research Institute Welsh & McKean Roads, Spring House, Pennsylvania, 19477-0776
&
Jeffery B. Press R. W. Johnson Pharmaceutical Research Institute Welsh & McKean Roads, Spring House, Pennsylvania, 19477-0776
Pages 1045-1051 | Received 08 Sep 1994, Published online: 23 Sep 2006
 
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Abstract

A convenient regiospecific preparation of unsymmetrical α-bromoketones, commencing from Meldrum's acid, has been developed. This procedure allows for preparation of α-bromoketones which are unobtainable in a pure state by other bromination methods and is compatable with introduction of a bromine atom in the presence of unsaturation using low-cost starting materials.

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