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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 14
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Original Articles

Michael Additions of 3,3- Dimethylacrylamides and Amines: Synthesis of the Growth Hormone Secretagogue L-692,585

Kenneth M. Wells Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
,
Kai Rossen Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
,
David Askin Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
,
Frederick W. Hartner Jr. Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
,
R. P. Volante Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
&
Paul J. Reider Merck Research Laboratories, Department of Process Research, P. O. Box 2000, Rahway, NJ, 07065-0900
Pages 2197-2202 | Received 15 Nov 1994, Published online: 23 Sep 2006
 
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Abstract

A highly efficient synthesis of the potent Human Growth Hormone Secretagogue L-692, 585 1 via a Micheal addition with a 3,3-dimethyl acrylic acid derivative 7 and (R)-1-amino-2-propanol 2 is presented.

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