Synthesis of N-t-Boc-4-S-t-Butyl-L-thiophenylalanine via Palladium Catalyzed Cross-Coupling Reaction of N-t-Boc-4-Iodo-L-phenylalanine with t-Butylthiol or Sodium t-Butylthiolate

Abstract

Cross-coupling reaction of N-t-Boc-4-iodo-L-phenylalanine with t-BuSH proceeded efficiently in the presence of Pd₂dba₃.CHCl₃/DPPF as the catalyst system. However, Pd₂dba₃.CHCl₃/DPPB was found to be more effective for coupling with t-BuSNa.