An Improved Alternative Norgestrel Preparation

Sergio FerriñTo Syntex División Química, Km. 4.5 Carretera Federal a Cuautla Civac Jiutepec Mor

Francisco López-Tapia Syntex División Química, Km. 4.5 Carretera Federal a Cuautla Civac Jiutepec Mor

Hećtor Salgado-Zamora Syntex División Química, Km. 4.5 Carretera Federal a Cuautla Civac Jiutepec Mor

Abstract

Ethynyl cerium chloride, prepared in situ from ethynyl magnesium bromide or lithium acetylide and anhydrous cerium chloride efficiently added to 13-ethyl-3-methoxy-gona-3,5-diene-17-one 2. Aqueous HCl hydrolysis of intermediate enol ether 3 gave high yields of norgestrel 4.

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An Improved Alternative Norgestrel Preparation

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An Improved Alternative Norgestrel Preparation

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