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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 8
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Original Articles

One-Stage Monosubstitution in Cyclen - Two Novel Examples

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Pages 1595-1603 | Received 18 Oct 1995, Published online: 15 Aug 2006
 

Abstract

Two new routes for alkylsubstituton of one in four amino groups in 1,4,7,10-tetraazacyclododecane (cyclen) are described, isomeric N-tris(hydroxy)butylcyclens 4 and 6 have been obtained in very good yields. Further carboxymethylation of other three amino groups afforded 10-tris(hydroxy)butyl-1,4,7-tris(carboxymethyl)cyclens 1 and 2.

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