A Novel Synthesis of the Antipsychotic Agent Ziprasidone

Frank J. Urban Pfizer Inc, Central Research Division, Process Research and Development Eastern Point Rd., Groton, CT, 06340

Ralph Breitenbach Pfizer Inc, Central Research Division, Process Research and Development Eastern Point Rd., Groton, CT, 06340

Dianne Gonyaw Pfizer Inc, Central Research Division, Process Research and Development Eastern Point Rd., Groton, CT, 06340

Abstract

A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the ortho-chlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.

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A Novel Synthesis of the Antipsychotic Agent Ziprasidone

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A Novel Synthesis of the Antipsychotic Agent Ziprasidone

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