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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 11
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Original Articles

Synthesis of 1-(2-Oxoalkyl)-2-acyltetrahydro-isoquinolines by α-Amidoalkylation of Methylene Active Carbonyl Compounds with N-Acyliminium Intermediates

Atanas P. Venkov Department of Chemistry, University of Plovdiv, Plovdiv, 4000, Bulgaria
&
Stela Statkova-Abeghe Department of Chemistry, University of Plovdiv, Plovdiv, 4000, Bulgaria
Pages 2135-2144 | Received 11 Oct 1995, Published online: 21 Aug 2006
 
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Abstract

Intermolecular α-amidoalkylation reaction of methylene active carbonyl compounds with N-acyliminium salts of 3,4-dihydroisoquinolines and acyl chlorides has been used for synthesis of 1-(2-oxoalkyl)-2-acyltetrahydroisoquinolines.

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