Deprotection and Direct Oxidative Deprotection of Trimethylsilyl Ethers to their Corresponding Alcohols and Carbonyl Compounds with Tris[trinitratocerium(IV)] Paraperiodate, [(NO₃)₃Ce]₃.H₂IO₆, in an Aprotic Solvent

Abstract

Deprotection of structurally different trimethylsilyl ethers to their corresponding alcohols has been achieved in refluxing benzene in the presence of tris[trinitratocerium(IV)] paraperiodte in a few minutes. This reagent has also been used successfuly for the direct oxidation of trimethylsilyl ethers to their corresponding carbonyl compounds. Benzylic double bonds are prone to cleavage reactions with this method.