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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 3
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Original Articles

An Improved Stereospecific Preparation of 7α-Alkoxycephalosporins

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Pages 445-452 | Received 14 Jun 1995, Published online: 21 Aug 2006
 

Abstract

7α-alkyloxy-cefalosporanate 1.1-dioxides were prepared starting from 7-ACA. The crucial step is the diazotation of the 7β-amino-cephem 5 with i-amylnitrite, followed by rhodium catalyzed exchange reaction to the desired 7α-alkoxy compounds.

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