Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 3
134
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Efficient Preparation and Resolution of Trans-1,2-cyclobutanedicarboxylic Acid and Some of its Derivatives

, &
Pages 483-493 | Received 04 Jul 1995, Published online: 21 Aug 2006
 

Abstract

The readily available cis/trans mixture of 1,2-cyclobutanedicarboxylic acid undergoes a quantitative isomerization in 12N HCl to the trans-diacid (as monitored by NMR spectroscopy). The latter is resolved to the (+)- and (-)-trans-diacids by modified literature and patented methods. The synthesis of the (S,S)-(-)-trans-diol and (S,S)-(+)-trans-ditosylate from the (S,S)-(+)-trans-diacid is also reported.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.