Convenient Access to 4,4-Disubstituted 4H-Chromenes. Synthesis of 4-Methyl-4-(4-methoxyphenyl)-benzo[h]-4H-chromene

Abstract

4-Methyl-4-(4-methoxyphenyl)-benzo[h]-4H-chromene is synthesised by condensation of 4-methoxyacetophenone and ethyl acetate in strong base, followed by coupling with 1-naphthol, reduction to the epimeric lactols and elimination of water.