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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 23
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Original Articles

(S)-2-Amino-3-(2,5-dimethylphenyl)-1,1-diphenyl-1-propanol: Synthesis and Application in Enantioselective Reduction of Prochiral Ketones

, , , , &
Pages 4415-4420 | Received 10 Apr 1996, Published online: 23 Aug 2006
 

Abstract

The title chiral amino alcohol 6 was prepared from (s)-3-(2,5-dimethylphenyl)-alanine methyl ester hydrochloride by its reaction with phenyl magnesium bromide. In the presence of 2 mol% of 6, the borane reduction of prochiral ketones gave optically active secondary alcohols in high yields with the ee's ranged from 40.5 to 100%.

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