A Convenient, Large-Scale Preparation of a Differentially Protected α-Aminoglycine Suitable for the Synthesis of α-Aminoglycine-Containing Peptides

Abstract

α-Boc-amino-Fmoc-glycine 6 was prepared in two steps from 9-fluorenyl-methylcarbamate 1, glyoxylic acid 3 and t-butyl carbamate 5. This compound is useful in Solid Phase Peptide Synthesis to prepare α-aminoglycine-containing peptides using Fmoc-strategy.