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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 26, 1996 - Issue 22
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Original Articles

5-Bromobarbituric Acid : A Mild and Selective Monobrominating Agent Employed in the Synthesis of the Gastrin Antagonist GR174152

Robert Bright Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
,
Steven J. Coote Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
,
Stephen Freeman Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
,
Doug Hayes Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
,
Gordon Smith Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
&
David Tapolczay Process Research Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road STEVENAGE, Herts SG1 2NY
Pages 4195-4209 | Received 15 May 1996, Published online: 19 Aug 2006
 
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Abstract

5-Bromobarbituric acid (5) is a convenient reagent for the selective bromination of cyclic imine 3. A facile, in situ synthesis of this reagent involving a disproportionation reaction between barbituric acid and dibromobarbituric acid is described.

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