Synthesis of Two 6-N-Protected 9-N-Vinyladenines as Dipolarophiles in the Synthesis of Modified Nucleosides

Giselda Giglio Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Anna Napoli Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Antonella Leggio Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Angelo Liguori Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Antonio Procopio Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Carlo Siciliano Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

Giovanni Sindona Dipartimento di Chimica, Università della Calabria, I-87030, Arcavacata di Rende, (CS), ITALY

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Abstract

A new class of potential antiviral drugs is represented by isoxazolidine nucleosides. The paper reports on the synthesis of protected adenines useful as dipolarophiles in the preparation of analogues of dideoxyadenosine by 1,3-dipolar cycloaddition processes.

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Synthesis of Two 6-N-Protected 9-N-Vinyladenines as Dipolarophiles in the Synthesis of Modified Nucleosides

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Synthesis of Two 6-N-Protected 9-N-Vinyladenines as Dipolarophiles in the Synthesis of Modified Nucleosides

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