A Synthesis of novel IH-Imidazo[1,2-α]Indole-3-Carboxylates

Ian T. Forbes SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM 19 5 AW, UK

Helen K.A. Morgan SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM 19 5 AW, UK

Mervyn Thompson SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM 19 5 AW, UK

Abstract

A route to the uncommon imidazo[1,2-α]indole nucleus 1 is described via functionalisation and annelation of readily accessible 2-amino-indole-3-carboxylates 5. Intramolecular cyclization of a key 2-indolylformamidate 6 was utilised for the preparation of the 3,9-diester intermediates 7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

A Synthesis of novel IH-Imidazo[1,2-α]Indole-3-Carboxylates

Information for

Open access

Opportunities

Help and information

A Synthesis of novel IH-Imidazo[1,2-α]Indole-3-Carboxylates

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature