Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group

Abstract

The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5 _a-f) were obtained by removing the trityl groups with 5.0 M HCl solution. Alternatively, the hexamine ligands could be also prepared via amidation and reduction reactions. The synthetic routes described here are mild, efficient and easy to handle.