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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 1
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Original Articles

Reactivity of Benzylic Acylammonium Chlorides. A Novel Method for the Synthesis of N-Phenacylamides

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Pages 1-9 | Received 15 May 1996, Published online: 19 Aug 2006
 

Abstract

Tertiary amines 1 reacted with acid chlorides 2 to give corresponding benzyl chlorides and N-phenacylamides 4 . Counterion in species 3 attacked preferentially the benzylic methylene. Effect of substituents in the benzyl group on the reactivity of acylammonium chlorides 3 was investigated.

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