Stereoselecive Synthesis of 3-Alkylcinnamic Esters via Coupling Reaction of (2Z)-3-(Aryltelluro)cinnamic Esters in Presence of CuI

Abstract

Coupling reaction of (2Z)-3-(aryltelluro) cinnamic esters with Grignard reagents in presence of CuI produced trisubstituted alkenes containing ester groups with retention of configuration.

Notes

In lit. 4, Uemura have used cat. amount Ni(PPh₃)₂Cl₂ to catalysize the coupling reaction of ethyl (Z)-3-phenyltelluropropenoate with phenyl Grignard rengent, but he obtained the coupling product only in 28% yield.