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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 19
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Original Articles

Oxidation of Steroidal 5-En-3β-ol with Pyridinium Chlorochromate: Isolation of Key Intermediate, Steroidal 6β-Hydroxy-4-en-3-one

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Pages 3419-3430 | Received 04 Mar 1997, Published online: 22 Aug 2006
 

Abstract

The PCC oxidation of 5-en-3β-ol steroids proceeds to 4-en-3,6-dione through the intermediate 5-en-3-one. The isolation of another key intermediate, steroidal 6β-hydroxy-4-en-3-one guides an understanding of the mechanism involved.

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