Nucleophilic Substitution of an Acyl Azide: General Method for the Preparation of 5-Amino-3-methyl-4-isoxazolecarboxylic Acid Amides and Hydrazides

Abstract

We describe a convenient and general method for preparation of 5-amino-3-methyl-4-isoxazolecarboxylic acid amides and hydrazides from 5-amino-3-methyl-4-isoxazolecarboxylic acid azide. In this reaction, the acyl azide reacts with amines without Curtius rearrangement.

Notes

Supplementary data are available on request from the Cambridge Crystallographic Data Center, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U.K.