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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 27, 1997 - Issue 12
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Original Articles

An Efficient General Synthesis of Squarate Esters

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Pages 2177-2180 | Received 24 Jan 1997, Published online: 22 Aug 2006
 

Abstract

An efficient and general method for the synthesis of alkyl squarates is presented. This involves the reactions of squaric acid with the desired alcohol in the presence of an orthoformate. This was applicable for the synthesis of dimethyl-, diethyl-, diisopropyl, di-n-butyl and di-t-butyl squarates in yields ranging from 77–97%. It is a convenient and safe method that can be accomplished on a multigram scale.

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