1-Bromo-3,3-bis(2-bromoethyl)alkanes: Precursors to 4-Substituted Quinuclidines and 1-Phosphabicyclo[2.2.2]octanes

Kerim A. Bairamov Organic Materials Research Group Department of Chemistry, Vanderbilt University, Nashville, TN, 37235

Andrew G. Douglass Organic Materials Research Group Department of Chemistry, Vanderbilt University, Nashville, TN, 37235

Piotr Kaszynski Organic Materials Research Group Department of Chemistry, Vanderbilt University, Nashville, TN, 37235

Abstract

1-Bromo-3,3-bis(2-bromoethyl)octane has been synthesized from tetrahydro-4H-pyran-4-one in 6 steps and 18% overall yield. This method is more convenient, gives higher overall yields and is potentially more general than those previously reported for related tribromides.

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1-Bromo-3,3-bis(2-bromoethyl)alkanes: Precursors to 4-Substituted Quinuclidines and 1-Phosphabicyclo[2.2.2]octanes

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1-Bromo-3,3-bis(2-bromoethyl)alkanes: Precursors to 4-Substituted Quinuclidines and 1-Phosphabicyclo[2.2.2]octanes

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