High Yield Phase Transfer N-alkylation of Some Benzodiazepines by Esters of ω-Halo Acids

Abstract

Different i, 4-benzodiazepinyl acetic and propionic acids were prepared by hydrogenolysis of benzyl or hydrolysis of the corresponding ethyl esters which were obtained by phase transfer alkylation of respective amides with benzyl bromoacetate and benzyl or ethyl 2-bromopropionate.

Notes

results will be published elsewhere

Bzd-H: benzodiazepine aromatic protons.

Ph-H: benzyl aromatic protons.