Abstract
The preparation of two new propellanes containing the oxazino-oxazine moiety is described. The structure of 2,7-dioxa-5,10-diaza[4.4.4] propellane was determined by X-ray crystallographic analysis
Notes
Compound 1: m.p. 144–146°C; 1H NMR (270 MHz, CDCl3) δ: 4.01 (1H, ddd, J=12, 11, 4 Hz, H-3ax), 3.74 (1H, dd, J=11, 4 Hz, H-3eq), 3.50 (1H, ddd, J=12, 11, 4 Hz, H-4ax), 2.50 (1H, dd, J=12, 4 Hz, H-4eq), 2.60 (1H, m, H-11ax), 1.50–1.80 (2H, m, H-12ax, eq) and 1.00–1.25 (1H, m, H-11eq) ppm; 13C NMR (67.8, MHz, CDCl3) δ: 84.0 (C-1), 62.6 (C-3), 39.1 (C-4), 32.7 (C-11) and 23.2(C-12) ppm; MS, m/z (%):198, (M+, 2), 167 (7), 154 (5), 139 (5), 112 (19), 98 (100), 85 (20), 55 (27), 36 (41); IR v max (KBr): 3302, 2956, 2928, 1636, 1082, 1034, 924, 830 cm−1
Compound 2: m.p. 224–225°C; 1H NMR (270 MHz, DMSO-d6) δ: 7.05 (s, 1H, NH), 6.75–6.52 (4H, m, arom.) and 1.83–1.06 (4H, m, aliphat.) ppm; 13C NMR (67.80 MHz, DMSO-d6) δ: 141.0 (C-3), 129.8 (C-4), 120.7 (C-17), 118.3 (C-16), 115.6 (C-15), 114.0 (C-18), 81.8 (C-1), 32.6 (C-11) and 22.7 (C-12) ppm; MS, m/z (%), 294 (M+ 55), 265 (2), 237 (1), 187 (100), 158 (18), 146 (17), 120 (7), 93 (9), 65 (12), 28 (88); IR v max (KBr): 3334, 2926, 1608, 1502, 1274, 1236, 1006, 944, 870 cm−1
Crystal data: Colorless cubic crystals of compound 1, C10H18N2O2 (M=198.26 gmol−1), crystallized in the monoclinic space group C 2/c, crystal dimensions 0.3 x 0.4 x 0.5 mm,3 a=12.740(1), b=7.349(1), c=11.366(1) Å, β=109.943(3)°, V=1000.52(6) Å,3 by least squares refinement on diffractometer angles for 24 automatically centered reflections, Z=4, ρcalcd=1.31 Mgm,−3 μ=0.09 mm.−1 A total of 1253 reflections was measured, of which 1088 were independent and of these 662 were considered observed [F>3σ(F)], absorption correction: DIFABS (min: 0.65, max: 1.20), corrections were made for Lorentz and polarization effects. Solution and refinement: direct methods (SHELXS-86) for structure solution. Nonhydrogen atoms were refined anisotropically, hydrogen atoms were found by difference Fourier rmaps and refined with an overall isotropic thermal parameter (CRYSTALS, Program for Refinement of Crystal Structures, D.J. Watkin, J.R Caruthers, P.V. Betteridge, Univ. Oxford, version 9, 1994). R=0.047, Rw=0.045 from 662 reflections with F>3σ(F) for 92 variables against /F/, w=1.0, s=2.69. Largest residual electron density peak/ hole in the final difference map: ρmax=0.26, ρmin= −0.20 e-/Å3