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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 28, 1998 - Issue 22
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Original Articles

An Improved Preparation of 4-Hydroxymethyl-L-Phenylalanine

, &
Pages 4279-4285 | Received 15 May 1998, Published online: 11 Mar 2009
 

Abstract

Palladium-catalyzed hydroformylation of methyl esters of N-Boc-L-tyrosine triflate (1a) and N-Boc-4-iodo-L-phenylalanine (1b) followed by reduction with sodium borohydride and standard deprotection procedures affords the title compound in 77 and 83% overall yield, respectively.

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