A New Synthesis of Roxatidine Acetate

Velichko Tarpanov Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Radoslav Vlahov Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Miho Penkov Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Dikran Krikorian Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Stoyan Parushev Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Pepa Mechkarova Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

Nely Angelova Institute for Antibiotic Research, “Antibiotic” Co, Razgrad, Bulgaria

Walter Schunack Institut fur Pharmazie, Freie Universitat Berlin, Königin-Luise-Str.2+4, 14195, Berlin, Germany

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Abstract

A new four-step synthesis of N-{3-[3-(l-piperidinylmethyl)-phenoxy]propyl}acetoxyacetamide hydrochloride has been performed. The key aralkyl ether was synthesized in high yield under moderate conditions. A suitable scaling up permits a bulky production of the drug in 98.5% purity.

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A New Synthesis of Roxatidine Acetate

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A New Synthesis of Roxatidine Acetate

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