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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 1
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Original Articles

A New Synthesis of Roxatidine Acetate

, , , , , , & show all
Pages 15-20 | Accepted 22 May 1998, Published online: 17 Sep 2007
 

Abstract

A new four-step synthesis of N-{3-[3-(l-piperidinylmethyl)-phenoxy]propyl}acetoxyacetamide hydrochloride has been performed. The key aralkyl ether was synthesized in high yield under moderate conditions. A suitable scaling up permits a bulky production of the drug in 98.5% purity.

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