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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 29, 1999 - Issue 1
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Original Articles

Fmoc-Peptide Acid Chlorides in Fragment Coupling: Synthesis of β-Casomorphin by 3+2 Divergent Approach

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Pages 79-91 | Accepted 25 Apr 1998, Published online: 17 Sep 2007
 

Abstract

Fmoc-peptide acid chlorides are prepared and used as rapid and efficient coupling agents in fragment coupling. Thus the synthesis of the model tetrapeptide Leu-Ala-Gly-Val and P-casomorhin (Tyr-Pro-Phe-Pro-Gly) are accomplished by the (2+2) and (3+2) divergent approach respectively.

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