Application of Microwave Irradiation Techniques for the Syntheses of Cinnamic Acids by Doebner Condensation

Abstract

The reaction rate of Doebner condensation to achieve cinnamic acids can be dramatically enhanced by irradiating the reaction mixture containing an aromatic aldehyde, malonic acid, pyridine and a trace of piperidine with a commercial microwave oven. Ten cinnamic acids were synthesized within 2-5 min in excellent yields.