An Efficient Procedure for the Synthesis of Spiro (3H-Indole-3,4′ (1′H)pyrano[2,3-C]pyrrole]-5′-carbonitriles Using Solid Inorganic Supports and Microwave Activation

Abstract

Microwave irradiation accelerates the Michael condensation of 3-dicyanomethylene-2H-indole-2-one with 2-pyrrolidone/ N-methy1-2-pyrrolidone (i) adsorbed on neutral alumina in “dry media” (ii) using absolute ethanol as energy transfer medium. 3-Dicyanoniethylene-2H-indol-2-one was synthesized under microwave irradiation using indole-2,3-dione and malononitrile. The results were compared with those obtained following the classical method. The advantages obtained by the use of microwave irradiation are demonstrated.