Synthesis of Substituted 3-Aminocoumarins from Ethyl N-2-Hydroxyarylideneglycinates

Abstract

3-Aminocoumarin and its derivatives are prepared by a thermal (150-170°C) conversion reaction on the corresponding ethyl N-2-hydroxyarylidene-glycinates,[2-HOC₆H₃(X)CH=NCH₂CO₂C₂H₅; X = H, 5-Br, 5-OH, 5-NO₂, 3-OMe, 4-OMe, and 5,6-benzo], which are synthesized by condensing ethyl glycinate hydrochloride with substituted salicylaldehyde.