An Improved and Practical Sharpless Oxidation of Primary Alcohols to the Carboxylic Acids

Mahavir Prashad Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Yansong Lu Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Hong-Yong Kim Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Bin Hu Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Oljan Repic Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Thomas J. Blacklock Process Research & Development, Chemical & Analytical Development Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey, 07936, USA

Abstract

An improved and practical procedure for the oxidation of primary alcohols to the carboxylic acids under Sharpless's conditions (NaIO₄/RuCl₃.H₂O/water/acetonitrile) using ethyl acetate as the solvent, in place of toxic and ecologically undesirable carbon tetrachloride, is described.

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An Improved and Practical Sharpless Oxidation of Primary Alcohols to the Carboxylic Acids

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An Improved and Practical Sharpless Oxidation of Primary Alcohols to the Carboxylic Acids

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