https://orcid.org/0000-0002-9068-0673
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SUMMARY
Mesenchymal stem cells (MSCs) are multipotent progenitors that express markers such as CD73, CD44, CD29, CD90, and CD105. MSCs produce growth factors and cytokines, which are crucial in regulating haematopoiesis and supporting it. The ability of MSCs to differentiate into osteoblasts, adipocytes, chondrocytes, and myocytes is one of their unique characteristics. MSCs can be used in research to better understand bone mineralisation during osteogenesis, the pathogenic potential of infectious bursal disease viruses, and the interactions between MSCs. An appropriate stem cell model is MSCs, as they have several advantages, including their availability, proliferation, and immune-modulatory properties. The benefit of using MSCs beyond immunomodulatory cell therapy is that they allow for coculture with pathogenic organisms that cause chicken dermatitis disorders, and the ability to eliminate antibiotic growth promoters. This review summarises the current knowledge about the general characterisation of MSCs and their application in chickens as model organisms.
Acknowledgements
We want to thank the research deputy of the Ferdowsi University of Mashhad for your support.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author contribution
Conceptualisation: [Abolfazl Ghaniei], … ; Methodology: [Soheil Sadr/Narges Lotfalizadeh], … ; Formal analysis and investigation: [Soheil Sadr/Narges Lotfalizadeh], … ; Writing – original draft preparation: [All Authors]; Writing – review and editing: [Narges Lotfalizadeh/Soheil Sadr/Pouria Ahmadi Simab], … ; Funding acquisition: [Self-funding], … ; Supervision: [Abolfazl Ghaniei]. All authors checked and approved the final version of the manuscript for publication in the present journal.
Data availability statement
The datasets generated during and analysed during the current study are available from the corresponding author upon reasonable request.
Ethical consideration
Ethical issues (including plagiarism, consent to publish, misconduct, data fabrication and/or falsification, double publication and/or submission, and redundancy) have been checked by all the authors.