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Abstract
Extract
Johne's disease of cattle is an important economic problem in many countries. Vaccination offers one of the most promising methods of control, but has the disadvantage that cattle so vaccinated may react to the tuberculin test; vaccination may therefore interfere with tuberculosis eradication. Early French work by Vallée and Rinjard (Citation1926) had indicated that vaccination did not result in a positive reaction to a subsequent mammalian tuberculin test, but Doyle (Citation1945), in the United Kingdom, used improved tuberculins (intradermal neck test) and showed that a majority of vaccinated calves gave positive tuberculin reaction 1 to 2 months after vaccination. Buddle (Citation1953), in New Zealand, has obtained strong positive mammalian tuberculin reactions in experimental calves 3 months after vaccination. Stephens (Citation1955) observed vaccinated New Zealand cattle and reported that cattle one year after vaccination gave strong johnin reactions, slightly less avian tuberculin reactions, and moderate mammalian tuberculin reactions. He believed that any confusion regarding the positive mammalian reaction could be solved by examination for the vaccination nodule and conducting a comparative test; however, Doyle (Citation1953) has shown that goats vaccinated against Johne's disease and infected with tuberculosis may give higher avian tuberculin than mammalian tuberculin reactions; use of a comparative test might, therefore, fail to diagnose tuberculosis in vaccinated cattle.