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Abstract
Extract
It would seem from the recent report by Murray et al. (Citation1958) that success has at length attended the many attempts by workers at the Peter Bent Brigham Hospital (U.S.A.) to achieve functional renal homografts. In experimental surgery extending over a period of some thirteen years, numerous endeavours have been made to overcome the inherent obstacles to successful kidney transplantation; some transplants have worked for a month or so, but ultimately all have ended in failure, and it appeared that the mutual immunological reactions of host against graft, and graft against host, were so formidable as to defy solution.