Local reactions in sheep to clostridial vaccines

Abstract

Extract

Each year, several million sheep are injected with clostridial vaccines in New Zealand; though this must safeguard the animals, it is of overriding importance that the vaccine should be “safe”. The British Veterinary Codex (1965) recommends to manufacturers that a sample of each batch of vaccine should be injected into the intended animal species as a safety test. For pulpy kidney vaccine, twice the maximum dose recommended on the label injected subcutaneously should produce no significant local or systemic reaction in sheep during an observation period of seven days.