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Abstract
Extract
The increased vascular permeability that follows the intrapleural injection of turpentine in the sheep is due to the local re-ease of histamine and is continued by the activation of other mechanisms (Lancaster and Vegad, Citation1967). In further studies of the inflammatory response, an attempt was made to deplete the skin locally of its histamine content. It was found that the intra-dermal injection of a total of 80 mg/kg of compound 48/80, a histamine liberator, into a 20 kg lamb, caused acute respiratory distress and death. Death was presumed to be due to the release of lethal amounts of histamine by this compound. To investigate the sensitivity of the sheep to histamine, the toxicity of compound 48/80 and of histamine was tested.