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Abstract
Extract
It is clear that the early permeability response in the sheep that follows chemical and thermal injury, is mediated by histamine (Lancaster and Vegad, Citation1967; Vegad, Citation1971a, Citationb). This is similar to the situation in the rat and the guinea-pig (Spector and Willoughby, Citation1965). In contrast to the situation in the rat and the guinea-pig, various nucleosides (Vegad, Citation1970c), hyaluronidase (Vegad, Citation1970c), 5-hydroxytryptamine, turpentine-induced pleural exudates and the lymph node cell extracts also release histamine in the sheep skin (Vegad, Citation1967). From these results it was thought possible that cutaneous antigen-antibody reactions might also release histamine in the sheep, and this possibility has been investigated in the present experiments.